What do humans and Labradors have in common?
You might have more in common with a Labrador than you think — especially when it comes to appetite.
Scientists at the University of Cambridge have discovered that five specific genes responsible for overeating and obesity in Labradors are also present in humans — and they function in remarkably similar ways.
The lead gene, DENND1B, affects the leptin–melanocortin pathway, which plays a key role in regulating hunger and energy balance in the brain. In affected Labradors, this leads to a constant sense of hunger and, on average, 8% more body fat than their peers. For humans, it might help explain why some people feel driven to eat beyond what’s needed.
The researchers emphasize: this isn’t about willpower or personality. It’s biological predisposition — and it can't be fixed by gene editing, since these genes are also involved in other essential (and poorly understood) functions.
Instead, awareness is key: for both dogs and humans, the best defense is a disciplined diet, regular exercise, and structured meals. Because sometimes, hunger is hardcoded.
